Adjuvant immunotherapy with BCG in stage II malignant melanoma
β Scribed by M. J. Byrne; G. van Hazel; P. M. Reynolds; W. M. Lemish; C. D. J. Holman
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 223 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-4790
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β¦ Synopsis
Abstract
Fortyβone patients were treated with BCG immunotherapy following block dissection of lymph nodes involved with malignant melanoma. A control group of similar patients who received no immunotherapy was drawn from a population consisting of all patients with malignant melanoma diagnosed in Western Australia in the period from January 1, 1975 to December 31, 1976. The diseaseβfree survival and overall survival of BCGβtreated patients were not different from that of the control group, who received no immunotherapy. The findings do not support the use of this type of immunotherapy as an adjuvant to surgery in the treatment of patients with stage II malignant melanoma.
π SIMILAR VOLUMES
Eighty-two patients with invasive malignant melanoma and no distant metastases were prospectively randomized following their surgical treatment to 1) observation; 2) chemotherapy with Dacarbazine (DTIC) 200 mg/M2 I.V. daily X 5 every 4 weeks and Estracyt 15 mg/kg orally daily for 1 year; and 3) immu
Autopsy slides from 22 melanoma patients who received bacille Calmette-Guerin BC'G immunotherapy and who had a postmortem examination at the U C L A Center for the Health Sciences were examined for the presence o f granulomas. Granulomas were found i n six patients (29%) who received BCX but not in