Adjuvant chemotherapy of childhood posterior fossa ependymoma: Cranio-spinal irradiation with or without adjuvant CCNU, vincristine, and prednisone: A Childrens Cancer Group study
✍ Scribed by Evans, Audrey E.; Anderson, James R.; Lefkowitz-Boudreaux, Ilene B.; Finlay, Jonathan L.
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 605 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0098-1532
No coin nor oath required. For personal study only.
✦ Synopsis
In 1975, members of The Children's Cancer Croup (CCG) initiated a trial for patients with infratentorial medulloblastomas and ependymonas. Patients, all of whom received post-operative cranio-spinal irradiation (CSI), were randomized to receive or not receive adjuvant chemotherapy (CT) with lomustine (CCNU), vincristine, and prednisone for 1 year. Thirty-six of the 42 patients with ependymoma entered on study were suitable for analysis; 22 received combined modality therapy and 14 irradia-tion (RT) alone. The failure-free survival (FFS) for the entire sample at 10 years is 36% and overall survival ( 0 s ) 39%, with no difference in outcomes between the two regimens. Survival was better for females (73%) than males (21%) and for those older than 10 years (51% vs. 31%). There were two toxic deaths in the group receiving CT. We conclude from this study with long-term follow-up that the CT used was not effective in improving the outcome in children with ependymoma.