Following curative resection for gastric adenocarcinoma, 142 patients were randomized to receive adjuvant chemotherapy of methyl-CCNU and 5-FU or to be closely followed without chemotherapy. The median patient has been followed for four years. At the present time, there have been 38 recurrences and
Adjuvant chemotherapy for resectable gastric cancer: A preliminary report
β Scribed by Fong-Fu Chou; Shyr-Ming Sheen-Chen; Po-Pen Liu; Feng-Chi Chen
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 295 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
β¦ Synopsis
In this prospectively random study, the effect of oral Ftorafur as an adjuvant Chemotherapy was compared with that of oral placebo in patients with Stage I1 and Stage I11 gastric cancer. Patients had undergone a subtotal gastrectomy with a resection margin that should have been free of tumors. Ftorafur (I0 mg/kg) was given daily to 59 Group A patients. Multiple vitamins were given twice a week to 56 Group B patients. We found that there was no statistical significance in Stage I1 patients with regard to survival. In Stage IiI patients, those treated with oral Ftorafur had better 3-year and 5-year survival rates than those receiving oral placebo. This preliminary report on this ongoing study seems to indicate that long-term postoperative Ftorafur treatment may be beneficial to Stage I11 gastric cancer patients.
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