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Adinazolam, a new triazolobenzodiazepine, and imipramine in the treatment of major depressive disorder

✍ Scribed by Jay D. Amsterdam; Myron Kaplan; Larry Potter; Lawrence Bloom; Karl Rickels

Publisher: Springer
Year: 1986
Tongue: English
Weight: 582 KB
Volume: 88
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00178511

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✦ Synopsis

This study evaluated the clinical efficacy and safety of a new triazolobenzodiazepine, adinazolam, and imipramine in 40 patients with carefully diagnosed major depressive disorder. Overall, adinazolam was found to be as effective as imipramine. In addition, when patients with more severe, melancholic, subtype of depression were examined, adinazolam was also as effective as imipramine. With the exception of sedation, adinazolam patients demonstrated fewer overall adverse events than imipramine subjects. These results suggest that adinazolam may represent an interesting antidepressant compound.

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