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Adhesion of metastatic and non-metastatic carcinoma cells to glass surfaces

✍ Scribed by M. Cottler-Fox; W. Ryd; B. Hagmar; C. H. Fox

Publisher: John Wiley and Sons
Year: 1980
Tongue: French
Weight: 711 KB
Volume: 26
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910260523

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Adhesion in vitro is described in cells from a tumor pair originating from a single methylcholanthrene‐induced mouse carcinoma. One member of this tumor pair shows a high incidence of metastases while the other does not metastasize. Cells from the non‐metastasizing carcinoma were found to form close and focal contacts with a glass substrate consecutively, as do normal mouse kidney epithelial cells. Cells from the metastasizing carcinoma, however, had only limited areas of close contact and generally failed to form focal contacts. It is suggested that this alteration in cell‐substrate adhesion contributes to the release and mobility of metastatic cells.

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