## Abstract The neural cell adhesion molecule (NCAM) plays a crucial role in neuronal development, regeneration, and synaptic plasticity associated with learning and memory consolidation. Homophilic binding of NCAM leads to neurite extension and neuroprotection in various types of primary neurons t
β¦ LIBER β¦
Adhesion molecule signalling: not always a sticky business
β Scribed by Cavallaro, Ugo; Dejana, Elisabetta
- Book ID
- 109959519
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 425 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1471-0072
- DOI
- 10.1038/nrm3068
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## Background Molecular spacing is important for cell adhesion in a number of ways, ranging from the ordered arrangement of matrix polymers extracellularly, to steric hindrance of adhesion/signaling complexes intracellularly. This has been demonstrated using nanopatterned RGD peptides, a canonical