Adhesion Forces between LewisX Determinant Antigens as Measured by Atomic Force Microscopy

✍ Scribed by Christophe Tromas; Javier Rojo; Jesús M. de la Fuente; Africa G. Barrientos; Ricardo García; Soledad Penadés

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 99 KB
• Volume: 40
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3773(20010817)40:16<3052::aid-anie3052>3.0.co;2-q

✦ Synopsis

The adhesion forces between individual molecules of Lewis(X) trisaccharide antigen (Le(X) ) have been measured in water and in calcium solution by using atomic force microscopy (AFM, see graph). These results demonstrate the self-recognition capability of this antigen, and reinforce the hypothesis that carbohydrate-carbohydrate interaction could be considered as the first step in the cell-adhesion process in nature.