✦ LIBER ✦

Adhesion and spreading of cells on charged surfaces

✍ Scribed by N.G. Maroudas

Publisher: Elsevier Science
Year: 1975
Tongue: English
Weight: 528 KB
Volume: 49
Category: Article
ISSN: 0022-5193
DOI: 10.1016/s0022-5193(75)80044-0

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✦ Synopsis

Rival theories of cell adhesion are divided into long-range or contact, respectively. An experimental observation capable of deciding between them is the increasing attachment of negatively charged ceils to surfaces of increasing negative charge density. These results would appear to refute hypotheses based solely on the balance between long-range electrostatic and dispersive forces; but they are not incompatible with bridging through polymer adsorption. The crucial difference is that negative groups on a surface are necessarily repulsive to the cell at long range, but at contact range they can strongly bind polarizable or amphoteric links of the polymer chains in the cell coat.

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