Adenylate kinase isoenzyme patterns in tissues of people of different phenotype

✍ Scribed by D. J. H. Brock

• Book ID: 104785156
• Publisher: Springer
• Year: 1970
• Tongue: English
• Weight: 477 KB
• Volume: 4
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00486099

✦ Synopsis

Three distinct isoenzyme sets have been demonstrated for adenylate kinase (AK) from human tissues by the technique of starch gel eleetrophoresis. In adult and fetal muscle, liver, kidney, brain, spleen, lung, and leukocytes the same set was found, though individual bands had different intensities. In adult red cells and in fetal red cells separate and distinctive isoenzyme sets were observed. However, in all tissues, adult and fetal, the phenotype of an individual was recognizable by the presence or absence of a characteristic cathodal band. The apparent anomaly of the same phenotype being expressed in different isoenzyme sets was resolved by the demonstration that in adult and fetal red cells AK eomplexed with hemoglobin. The implications of this complex are briefly discussed.