Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study
β Scribed by M.A.W. MILLER; R.J. MORGAN; C.S. THOMPSON; D.P. MIKHAILIDIS; J.Y. JEREMY
- Book ID
- 115197728
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 527 KB
- Volume
- 74
- Category
- Article
- ISSN
- 1464-4096
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Glibenclamide enhanced the activity in the rat of guanylate cyclase in a number of extra-pancreatic tissues. Thus, glibenclamide enhanced guanylate cyclase activity in vitro two- to threefold in liver, kidney, heart, spleen and colon at a concentration of 1 mumol/l. Dose-response curves of glibencla
## Background: The consequences of experimental diabetes on membrane lipids, beta-adrenergic stimulation of adenylate cyclase activity, and g-protein levels in the prostate gland are not defined. ## Methods: Prostatic membranes from control and streptozotocin (stz)-diabetic rats were used to stud