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Adenovirus receptors: implications for tropism, treatment and targeting

โœ Scribed by Niklas Arnberg

Book ID
104590672
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
386 KB
Volume
19
Category
Article
ISSN
1052-9276

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โœฆ Synopsis

Abstract

Adenoviruses (Ads) are the most frequently used viral vectors in gene therapy and cancer therapy. Obstacles to successful clinical application include accumulation of vector and transduction in liver cells, coupled with poor transduction of target cells and tissues such as tumours. Many host molecules, including coagulation factor X, have been identified and suggested to serve as mediators of Ad liver tropism. This review summarises current knowledge concerning these molecules and the mechanisms used by Ads to bind to target cells, and considers the prospects of designing vectors that have been detargeted from the liver and retargeted to cells and tissues of interest in the context of gene therapy and cancer therapy. Copyright ยฉ 2009 John Wiley & Sons, Ltd.

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โœ Liesbeth Lenaerts; John H. McVey; Andrew H. Baker; Laura Denby; Stuart Nicklin; ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 184 KB

## Abstract ## Background For adenovirus vectors derived from human serotype 5 (Ad5), the efficiency and safety after intravascular delivery is hindered by their sequestration in nontarget tissues, predominantly the liver. The latter is largely dictated by adenovirus binding to blood coagulation z