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Adenovirus-mediated viral interleukin-10 gene transfer prevents concanavalin A-induced liver injury

✍ Scribed by Yan-Chun Zhou; Sui Chen; Jun-Jun Cao; Shao-Ying Chen; Yan-Fei Xie; Qing-Xia Niu


Book ID
119230044
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
973 KB
Volume
44
Category
Article
ISSN
1590-8658

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The liver appears to play an important role in immunological tolerance, for example, during allo-transplantation. We investigated tolerance mechanisms in the model of concanavalin A (ConA)-induced immune-mediated liver injury in mice. We found that a single injection of a sublethal ConA dose to C57B