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Adenovirus-mediated transduction of ribozymes abrogates HER-2/neu and pleiotrophin expression and inhibits tumor cell proliferation

โœ Scribed by Czubayko, F; Downing, S G; Hsieh, S S; Goldstein, D J; Lu, P Y; Trapnell, B C; Wellstein, A


Book ID
110038058
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
301 KB
Volume
4
Category
Article
ISSN
0969-7128

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## Abstract Silencing of a specific mRNA using double stranded RNA oligonucleotides represents one of the newest technologies for suppressing a specific gene product. Small interfering RNA (siRNA) are 21 nucleotides long, double stranded RNA fragments that are identical in sequence to the target mR