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Adenovirus-mediated suicide gene therapy for experimental bladder cancer

โœ Scribed by Mark A. Sutton; Scott A. Berkman; Shu-Hsia Chen; Andreas Block; Truong D. Dang; Michael W. Kattan; Thomas M. Wheeler; David R. Rowley; Savio L.C. Woo; Seth P. Lerner

Book ID
119486694
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
973 KB
Volume
49
Category
Article
ISSN
0090-4295

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The efficacy of adenovirus (ADV)-mediated gene therapy to treat brain tumors was tested in a syngeneic glioma model. Tumor cells were transduced in situ with a replication-defective ADV carrying the herpes simplex virus thymidine kinase (HSV-tk) gene controlled by the Rous sarcoma virus promoter. Ex