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Adenovirus mediated prostate specific enzyme prodrug gene therapy using prostate

✍ Scribed by I Yoshimura; S Ikegami; S Suzuki; T Tadakuma; M Hayakawa; J.T Hsieh

Book ID: 117724299
Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 10 KB
Volume: 21
Category: Article
ISSN: 1078-1439
DOI: 10.1016/s1078-1439(03)00081-4

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## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar