Adenovirus-mediated interleukin-18 mutant in vivo gene transfer inhibits tumor growth through the induction of T cell immunity and activation of natural killer cell cytotoxicity

In vivo anti-tumor activity of combinati

In vivo anti-tumor activity of combinations of interferon alpha and interleukin-2 in a murine model. Correlation of efficacy with the induction of cytotoxic cells resembling natural killer cells

✍ Michael J. Brunda; Donna Bellantoni; Viveca Sulich 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 684 KB

The in vivo anti-tumor activity of 2 recombinant cytokines, interleukin-2 (rlL-2) and human hybrid interferon alpha (rHulFN-aA/D), were tested using the murine reticulum cell sarcoma M5076. Experimental hepatic metastases, following i.v. injection of tumor cells, and tumor growth and spontaneous met