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Adenovirus-mediated expression of both antisense ODC and AdoMetDC inhibited colorectal cancer cell growth in vitro

✍ Scribed by Bing ZHANG; Xian-xi LIU; Yan ZHANG; Chun-ying JIANG; Qing-shan TENG; Hai-yan HU; Wei WANG; Lei GONG


Book ID
111354992
Publisher
Nature Publishing Group
Year
2006
Tongue
Chinese
Weight
1008 KB
Volume
27
Category
Article
ISSN
1671-4083

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Polyamine depletion by ODC-AdoMetDC anti
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## Abstract ## Background Polyamine biosynthesis is controlled primarily by ornithine decarboxylase (ODC) and S‐adenosylmethionine decarboxylase (AdoMetDC). Polyamine concentrations are elevated in colorectal cancer. Depletion of polyamine content in colorectal cancer by chemotherapy is related to