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Adenovirus-Mediated Expression of Antisense Urokinase Plasminogen Activator Receptor and Antisense Cathepsin B Inhibits Tumor Growth, Invasion, and Angiogenesis in Gliomas

✍ Scribed by Gondi, C. S.


Book ID
127385028
Publisher
American Association for Cancer Research
Year
2004
Tongue
English
Weight
716 KB
Volume
64
Category
Article
ISSN
0008-5472

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## Abstract We have targeted the urokinase‐type plasminogen activator receptor (uPAR) with phosphorothioate antisense oligonucleotides (aODN) __in vitro__ to evaluate the anti‐invasive and anti‐proliferative effects of uPAR down‐regulation, as well as __in vivo__ to evaluate anti‐tumor and anti‐met