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Adenovirus-mediated dystrophin minigene transfer improves muscle strength in adult dystrophic (MDX) mice

✍ Scribed by Yang, L; Lochmuller, H; Luo, J; Massie, B; Nalbantoglu, J; Karpati, G; Petrof, B J


Book ID
110038161
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
204 KB
Volume
5
Category
Article
ISSN
0969-7128

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## Abstract ## Background The helper‐dependent adenovirus (HDAd) vector is less immunogenic and has a larger cloning capacity of up to 37 kb enough to carry the full‐length dystrophin cDNA. However, high and long‐term expression of dystrophin transduced to mature muscle still remains difficult. On