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ADENOVIRUS MEDIATED CYTOSINE DEAMINASE GENE TRANSDUCTION AND 5-FLUOROCYTOSINE THERAPY SENSITIZES MOUSE PROSTATE CANCER CELLS TO IRRADIATION

✍ Scribed by ANELLO, RUSSELL; COHEN, SETH; ATKINSON, GERTRUDE; HALL, SIMON J.


Book ID
122927827
Publisher
Lippincott Williams and Wilkins
Year
2000
Tongue
English
Weight
79 KB
Volume
164
Category
Article
ISSN
0022-5347

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Hypoxia response element-driven cytosine
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## Abstract ## Background We proposed to exploit hypoxia‐inducible factor (HIF)‐1Ξ± overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF‐1Ξ± to arrangements of hypoxia response elements.