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Adenovirus-mediated CD40 ligand gene-engineered dendritic cells elicit enhanced CD8+ cytotoxic T-cell activation and antitumor immunity

✍ Scribed by Liu, Yongqing; Zhang, Xuishu; Zhang, Weidong; Chen, Zhuang; Chan, Tim; Ali, Kaiser; Jia, Zongchao; Xiang, Jim

Book ID: 110018869
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 460 KB
Volume: 9
Category: Article
ISSN: 0929-1903
DOI: 10.1038/sj.cgt.7700429

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## Abstract ## Background Tumor antigen presentation by dendritic cells (DCs) to T cells in lymphoid organs is crucial for induction of antitumor immune responses. Fms‐like tyrosine kinase 3 ligand (Flt3L) is a regulator of hematopoietic cell development. ## Methods To investigate the potential