Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death
β Scribed by Sandig, Volker; Brand, Karsten; Herwig, Susanne; Lukas, Jiri; Bartek, Jiri; Strauss, Michael
- Book ID
- 109927701
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 760 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1078-8956
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## Wild -type P16ICDKNZ MTSI) cDNA, directed by the cytomegalovirus (CMV) immediate early promoter, was transfected into RT4 and RTI I 2 bladder-carcinoma cell lines bearing a mutated endogenous P16ICDKNZ gene and lacking endogenous P 16lCDKN2 respectively. In both cases, only transfected clones w