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Adenoviral transfer of the heme oxygenase-1 gene protects striatal astrocytes from heme-mediated oxidative injury

✍ Scribed by Zhi-Ping Teng; Jing Chen; Lee-Young Chau; Nicholas Galunic; Raymond F. Regan

Book ID
116761652
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
340 KB
Volume
17
Category
Article
ISSN
0969-9961

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## Abstract Hemin, the oxidized form of heme, is released from hemoglobin after CNS hemorrhage and may contribute to injury to surrounding tissue. The heme oxygenase (HO) enzymes catalyze the breakdown of hemin to biliverdin, carbon monoxide, and ferric iron. Although HO‐2, the isoform expressed pr