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Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-β-mediated chondrocyte proliferation and proteoglycan synthesis

✍ Scribed by A Scharstuhl; R Diepens; J Lensen; E Vitters; H van Beuningen; P van der Kraan; W van den Berg

Book ID
114348619
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
329 KB
Volume
11
Category
Article
ISSN
1063-4584

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## Abstract Transforming growth factor‐β (TGF‐β) is a multifunctional cytokine that regulates a wide variety of cellular processes including proliferation, differentiation, and extracellular matrix deposition. Dysregulation of TGF‐β signaling is associated with several diseases such as cancer and t