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Adenoviral-mediated gene transfer to enhance neuronal survival, growth, and regeneration

✍ Scribed by George M. Smith; Mario I. Romero


Book ID
101246039
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
98 KB
Volume
55
Category
Article
ISSN
0360-4012

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✦ Synopsis


Current treatments for disorders due to nervous system degeneration, either as result of an inherited deficit or in response to injury, offer little hope of impeding disease progression or of restoring function. The identification of molecules involved in neurodegeneration as well those that participate in neuronal survival,


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## Abstract ## Background The apical surface of polarized epithelial cells is relatively resistant to gene delivery by various agents including adenoviral vectors. Hepatocyte growth factor (HGF) dedifferentiates previously well‐polarized Madin‐Darby canine kidney (MDCK) cell monolayers by altering