Adenoviral expression of TDP-43 and FUS genes in adult rat motoneurons in vivo
โ Scribed by Kazuhiko Watabe; Keiko Akiyama; Shizuka Takaku; Emiko Kawakami
- Book ID
- 116777891
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 84 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0168-0102
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract ## Background Gene silencing in mammalian cells is possible with RNA interference (RNAi) with expression plasmids that encode for short hairpin RNAs (shRNA) that hybridize to a specific sequence within a target mRNA. The limiting factor in developing RNAi therapeutics in mammals is the
Gap junctions have been reported to play a pivotal role in coordinating embryonic development. Here we report the temporal and spatial pattern of connexin31 that has been found to be coexpressed with connexin43 in preimplantation rat embryos. Connexin31 and connexin43 transcripts are abundant in the
## Abstract The survival and functional maintenance of spinal motoneurons, both during the period of developmental cell death and in adulthood, have been shown to be dependent on trophic factors. In vitro experiments have previously been used to identify several survival factors for motoneurons, in