Adenosine-mediated synaptic inhibition: Partial blockade by barium does not prevent anti-epileptiform activity
✍ Scribed by Susanne Birnstiel; Urs Gerber; Robert W. Greene
- Book ID
- 104600436
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 650 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-4476
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✦ Synopsis
Adenosine-induced inhibition of evoked postsynaptic potentials (PSPs) and epileptiform burst firing in the CA1 subfield of rat hippocampal slices was studied with intracellular recordings in vitro. Adenosine (50 pM) caused a membrane hyperpolarization which was abolished during superfusion with 2 mM Ba2+. The adenosine-induced inhibition of the PSPs was still evident, although the magnitude of the effect was significantly reduced. Adenosine also reduced Ba2+-induced burst firing, but less effectively than it did bursts evoked by TEA (5 mM). The results suggest that adenosine inhibits synaptic transmission and epileptiform activity by at least 2 mechanisms: a postsynaptic barium-sensitive increase in gK and a presynaptic effect independent of this adenosineevoked outward potassium conductance. o 1992 WiIey-Liss, Inc.