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Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

✍ Scribed by Ugarkar, Bheemarao G.; DaRe, Jay M.; Kopcho, Joseph J.; Browne, Clinton E.; Schanzer, Juergen M.; Wiesner, James B.; Erion, Mark D.


Book ID
120365614
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
214 KB
Volume
43
Category
Article
ISSN
0022-2623

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Inhibition of adenylate kinase by P1,P5-
✍ William N. Valentine; Donald E. Paglia; Misae Nakatani; Richard A. Brockway πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 191 KB

P1,P5-di(adenosine 5')pentaphosphate (Ap5A) is an excellent inhibitor of human hemolysate adenylate kinase at concentrations near 2 microM and above. At ten times this concentration and in hemolysate enzyme assays under conditions described in this paper it appears not to alter reaction data in the