Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation

Endogenous IGFBP-3 is required for both

Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells

✍ Brian J. Leibowitz; Wendie S. Cohick 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views

## Abstract TNF‐α and IGF‐I exert opposing effects on mammary epithelial cell (MEC) growth and survival. However, both increase IGF binding protein‐3 (IGFBP‐3) expression, a multifunctional protein that plays both IGF‐dependent as well as independent roles in these processes. We have reported that