Adenosine as a possible inhibitor of killer T-cell activation in the microenvironment of solid tumours
โ Scribed by David W. Hoskin; Teresa Reynolds; Jonathan Blay
- Book ID
- 102277881
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- French
- Weight
- 178 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
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## Abstract Adenosine, a purine nucleoside found at high levels in solid tumors, is able to suppress the recognition/adhesion and effector phases of killer lymphocyteโmediated tumor cell destruction. Here, we demonstrate that adenosine, at concentrations that are typically present in the extracellu
## Abstract A variety of tumours injected into rats were found to rapidly stimulate cytotoxicity which was similar to naturallyโoccurring cytotoxicity of normal rats. Cytotoxic cells from the spleen and peritoneal cavity closely resembled NK cells in their lytic specificity and cellโsurface charact