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Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-d-aspartate effects

✍ Scribed by M. T. Tebano; A. Martire; N. Rebola; R. Pepponi; M. R. Domenici; M. C. Grò; M. A. Schwarzschild; J. F. Chen; R. A. Cunha; P. Popoli


Book ID
111179204
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
598 KB
Volume
95
Category
Article
ISSN
0022-3042

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This study investigated the modulatory actions of adenosine and ␥-aminobutyric acid (GABA) on several aspects of N-methyl-Daspartate (NMDA)-induced neurotoxicity, including neuronal loss, atrophy, necrosis, and calcium accumulation in the hippocampus. For this purpose, we combined unilateral intrahi