Adenosine A2A receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease
โ Scribed by M Ochi; S Shiozaki; H Kase
- Book ID
- 116786433
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 1002 KB
- Volume
- 127
- Category
- Article
- ISSN
- 0306-4522
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There is increasing evidence that adenosine (ADO) and dopamine (DA) interact directly in the basal ganglia via actions at ADO A,, and DA D2 receptors, respectively. The purpose of this study was to determine 1) the extent to which these receptors modulate endogenous GABA release in discrete regions
Behavioral and biochemical studies suggest that a negative interaction exists between adenosine A 1 and dopamine D 1 receptors in the brain and that this may contribute to the psychomotor effects of adenosine receptor agonists and antagonists. We examined the functional significance of A 1 and D 1 r