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Adenosine A1 receptors heterodimerize with β1- and β2-adrenergic receptors creating novel receptor complexes with altered G protein coupling and signaling

✍ Scribed by Chandrasekera, P. Charukeshi; Wan, Tina C.; Gizewski, Elizabeth T.; Auchampach, John A.; Lasley, Robert D.


Book ID
121734464
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
600 KB
Volume
25
Category
Article
ISSN
0898-6568

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## Abstract In the heart β~1~‐adrenergic (β1R) and adenosine A~1~ (A1R) and A~2A~ (A2AR) receptors modulate contractile and metabolic function. The interaction between these receptors was investigated at the level of G‐protein cycling by determining the effect of receptor agonists on the binding of