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Adenosine A1 receptor and ligand molecular modeling

✍ Scribed by Mark W. Dudley; Norton P. Peet; David A. Demeter; Herschel J. R. Weintraub; Ad P. Ijzerman; Gunnar Nordvall; Philip J. M. van Galen; Kenneth A. Jacobson

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 644 KB
Volume: 28
Category: Article
ISSN: 0272-4391
DOI: 10.1002/ddr.430280309

No coin nor oath required. For personal study only.

✦ Synopsis

This symposium provided a forum for presentations by the relevant groups on ligand design and ligand binding on the adenosine A, receptor. Agreement appears to exist that the "N6-C8" model of ligand binding to the receptor i s the preferred mode. A consensus has not yet been reached on the actual placement of the ligand in the receptor and the exact amino acids which interact in its binding. Two viable models exist at present. Both can be tested with selective site-directed mutagenic studies on the A, receptor as well as with additional designed ligands.

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