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Adenosine A 2A receptor agonists: CoMFA-based selection of the most predictive conformation

โœ Scribed by Doytchinova, I.; Valkova, I.; Natcheva, R.

Book ID
126789682
Publisher
Taylor and Francis Group
Year
2002
Tongue
English
Weight
177 KB
Volume
13
Category
Article
ISSN
1062-936X

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Selective and potent antagonists for the A 2A adenosine receptors have been described recently. The most potent compounds have a triazolo-pyrimidine structure, whereas 8-styryl-xanthines usually possess lower affinity at the A 2A receptor. We have examined the quantitative structure activity relatio