An earlier report (la) has shown the utility of 8-N3 cAMP (8-azidoadenosine-3', 5'-cyclic monophosphate) as a photoaffinity probe for cAMP binding sites in human erythrocyte membranes. The increased resolution obtained using a linear-gradient SDS polyacrylamide gel system now shows that: 1) both cAM
✦ LIBER ✦
Adenosine 3′,5′-monophosphate: Demonstration of a binding site specific for the cyclic nucleotide
✍ Scribed by Wai Yiu Cheung
- Book ID
- 118934958
- Publisher
- Elsevier Science
- Year
- 1970
- Tongue
- English
- Weight
- 281 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0024-3205
No coin nor oath required. For personal study only.
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## Abstract The extended Hückel theory (EHT) was used as a quantum mechanical approach for the determination of the best conformation of cyclic AMP. Both geometrical and quantum mechanical studies were necessary to ascertain the configuration of the sugar ring and phosphate ring. This was due to th