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Adenoid cystic carcinoma of the breast: Diagnosis by fine-needle aspiration

✍ Scribed by Dr. Michael W. Stanley; Edneia M. Tani; Lars-Eric Rutquist; Lambert Skoog

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
493 KB
Volume
9
Category
Article
ISSN
8755-1039

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✦ Synopsis

Adenoid cystic carcinoma rarely occurs as a primary breast malignancy. When seen in fine-needle aspiration (FNA) material, it is identical to its counterpart in the salivary glands. W e report six cases diagnosed by aspiration in patients aged 32-82 yr. The smears were highly cellular and featured extracellular spheres of metachromatic material. These were surrounded by small, uniform cells with bland nuclei and very little cytoplasm. Numerous similar cells occurred singly in the background. The cytologic dijyerential diagnosis of adenoid cystic carcinoma includes other entities that produce extracellular metachromatic spheres including collagenous spherulosis. W e describe and illustrate similar materialoriginating in inspissated secretions or stromal fragments from fibrocystic change and fibroadenoma, as well as injltrating ductal carcinoma. Diagnostic criteria for adenoid cystic carcinoma and the clinical relevance of distinguishing this rare tumor from typical injltrating ductal carcinoma are discussed. Diagn

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