Adenocarcinoma and transitional cell carcinoma occurring simultaneously in the urinary bladder (mixed tumor)

✍ Scribed by J. Peter Fegen; David J. Albert; Lester Persky

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 482 KB
• Volume: 3
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930030404

✦ Synopsis

Only five tumors of the urinary bladder containing both adenocarcinoma and transitional cell carcinoma have previously been reported. In spite of this apparent rarity, three patients have been treated a t the University Hospitals of Cleveland in the past 2 years with this 'mixed' malignancy. Abbreviated case histories, treatment, and follow-up are discussed. Two of the three patients are alive without evidence of tumor following treatment. The origin of adenocarcinoma appearing as a primary bladder neoplasm may be from a urachal rest, from glandular cells around the bladder neck, from malignant degeneration of cystitis cystica and cystitis glandularis, or from a primary change of transitional epithelium to glandular cancer. The mixed tumor may represent dual malignant degeneration of a common cell line or two primary cancers appearing coincidentally a t one time. The prognosis is poor, although the rarity of cases and short follow-up make efficacy of treatment difficult to evaluate.