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Adduction of catechol estrogens to nucleosides

✍ Scribed by Isabelle Jouanin; Laurent Debrauwer; Gwénola Fauglas; Alain Paris; Estelle Rathahao


Book ID
117213542
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
155 KB
Volume
67
Category
Article
ISSN
0039-128X

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Catechol estrogens, such as 2-hydroxyestriol, 2-hydroxyestradiol, and 2-hydroxyestrone, inhibit human liver dihydropteridine reductase noncompetitively with Ki values ranging from 1.5 to 4.6 X 10(-6)M. Catechol estrogens lose approximately half of their inhibitory potency if the C-2 hydroxyl groups