Addressing the Problems of Base Pairing and Strand Cyclization in Template-Directed Synthesis. A Case for the Utility and Necessity of “Molecular Midwives” and Reversible Backbone Linkages for the Origin of Proto-RNA

Addressing the Problems of Base Pairing

Addressing the Problems of Base Pairing and Strand Cyclization in Template-Directed Synthesis : A Case for the Utility and Necessity of ‘Molecular Midwives’ and Reversible Backbone Linkages for the Origin of proto-RNA

✍ Nicholas V. Hud; Swapan S. Jain; Xiaohui Li; David G. Lynn 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 450 KB 👁 1 views

## Abstract Nucleic acid synthesis is precisely controlled in living organisms by highly evolved protein enzymes. The remarkable fidelity of information transfer realized between template and product strands is the result of both the spatial selectivity of the polymerase active site for __Watson–Cr