Eight protein-ligand complexes were simulated by using global optimization of a complex energy function, including solvation, surface tension, and side-chain entropy in the internal coordinate space of the flexible ligand and the receptor side chains [Abagyan, R.
✦ LIBER ✦
Addressing Protein Flexibility and Ligand Selectivity by “in situ Cross-Docking”
✍ Scribed by Matthias Zentgraf; Jasmine Fokkens; Christoph A. Sotriffer
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 197 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1860-7179
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## Abstract We report a novel technique for preparing cross‐linked protein membranes within microchannels by using an interfacial cross‐linking reaction. Glass microchannels with a Y input were assembled by using a simple adhesive bonding technique to achieve dual, parallel laminar flows. Membrane