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Additions and Corrections - The Protonation of Indoles: Position of Protonation.

✍ Scribed by Hinman, R. L.; Whipple, E. B.

Book ID
126330664
Publisher
American Chemical Society
Year
1962
Tongue
English
Weight
137 KB
Volume
84
Category
Article
ISSN
0002-7863

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Protonation Sites of Indoles and Benzoyl
Protonation Sites of Indoles and Benzoylindoles
✍ Francisco J. Hoyuelos; BegoΓ±a GarcΓ­a; Saturnino Ibeas; MarΓ­a S. MuΓ±oz; Ana M. Na πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 380 KB

## Abstract Indomethacine (**1**) and acemethacine (**2**) contain the substituents ‐OCH~3~, ‐CH~2~COOH, ‐CH~2~COOCH~2~COOH, C‐indole and O‐benzoyl, which are susceptible to protonation in highly acidic media. To determine the protonation sites and the substituent effects reliably, the dissociation