Additions and Corrections - Pteridinecarboxamide Diuretics. I. Reaction of 4,6-Diamino-5-nitrosopyrimidines with Substituted Malonamides.
✍ Scribed by Osdene, T. S.; Santilli, Arthur A.; McCardle, Lee E.; Rosenthale, Marvin E.
- Book ID
- 126067688
- Publisher
- American Chemical Society
- Year
- 1967
- Tongue
- English
- Weight
- 77 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0022-2623
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## Abstract 4‐(Acylamino)‐5‐nitrosopyrimidines react either by a reductive condensation to provide 8‐substituted guanines, or by a __Diels–Alder__ cycloaddition, or an ene reaction, to provide 6‐substituted pteridinones, depending on the nature of the acyl group and the reaction conditions. Experim
## Abstract Pteridines substituted with a 1,1‐, 1,2‐, or 1,1,3‐substituted alkenyl group (mostly (__E__)‐configured) at C(6) were synthesized in high yields by the intramolecular nitroso‐ene reaction of 4‐(alkenoylamino)‐2‐amino‐6‐benzyloxy‐5‐nitroso‐ and 4‐(alkenoylamino)‐2,6‐diamino‐5‐nitrosopyri