Additional Evidence for the Existence of Only One Kind of Transition State in the NABH4 Reduction of Aliphatic Ketones

✍ Scribed by G. L. Lemière; T. A. van Osselaer; F. C. Alderweireldt

• Publisher: Wiley (John Wiley & Sons)
• Year: 2010
• Weight: 387 KB
• Volume: 87
• Category: Article
• ISSN: 0037-9646
• DOI: 10.1002/bscb.19780871006

✦ Synopsis

Abstract

Only one isokinetic relation is found for the NaBH~4~ reduction of aliphatic ketones. The study includes acyclic and cyclic ketones, hindered and unhindered cyclohexanones, overall reaction rates and reaction rates of axial and equatorial attack on cyclohexanones. This strongly supports the view‐point that all these reactions proceed through only one kind of transition state. For aromatic ketones other correlations are found corresponding with other types of transition state.