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Additional acquisition of t(1;21)(p32;q22) in a patient relapsing with acute myelogenous leukemia withNUP98-HOXA9

✍ Scribed by Takatoshi Aoki; Toshihiro Miyamoto; Shuro Yoshida; Asataro Yamamoto; Takuji Yamauchi; Goichi Yoshimoto; Yasuo Mori; Kenjiro Kamezaki; Hiromi Iwasaki; Katsuto Takenaka; Naoki Harada; Koji Nagafuji; Takanori Teshima; Koichi Akashi

Book ID: 107618649
Publisher: Carden Jennings Publishing
Year: 2008
Tongue: English
Weight: 219 KB
Volume: 88
Category: Article
ISSN: 0925-5710
DOI: 10.1007/s12185-008-0198-9

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## Abstract The __AML1__ gene (also known as __RUNX1__) at 21q22 codes for core binding factor (CBF) α, which forms a heterodimer with CBF β that acts as a transcriptional activating factor. CBF is a critical regulator in the generation and differentiation of definitive hematopoietic stem cells and