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Addition of trimethylsilyl cyanide to aromatic ketones promoted by organic solutions of lithium salts

✍ Scribed by Gérard Jenner


Book ID
104260440
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
194 KB
Volume
40
Category
Article
ISSN
0040-4039

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The asymmetric addition of trimethylsily
✍ Yuri N Belokon; Brendan Green; Nicolai S Ikonnikov; Michael North; Vitali I Tara 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 217 KB

The use of a bimetallic titanium salen complex as a catalyst for the asymmetric addition of trimethylsilylcyanide to ketones is reported. The cyanohydrin trimethyisilyl ethers are obtained with enantiomeric excesses of up to 72% from reactions carried out at room temperature and atmospheric pressure