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Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

✍ Scribed by Loskog, A; Giandomenico, V; Rossig, C; Pule, M; Dotti, G; Brenner, M K


Book ID
110056882
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
254 KB
Volume
20
Category
Article
ISSN
0887-6924

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## Abstract The therapeutic success of adoptive therapy with chimeric antigen receptor (CAR) engineered T cells depends on the appropriate costimulation of CD3ΞΆ to induce full T cell activation. Costimulatory endodomains of the CD28 family are therefore fused with CD3ΞΆ in a dual signalling CAR. Ser