Addition of penicillin Grignards to glyoxals a synthesis of novel penam ketoalcohols

✍ Scribed by Larry A. Reed III; Dan A. Charleson; Robert A. Volkmann

• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 232 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)96318-4

✦ Synopsis

The condensation of penicillin Grignards with substituted glyoxals leads to the synthesis of novel penam a-ketoalcohol antibacterials which are structurally related to several clinically useful penicillins.

Over the last forty years, an enormous effort has been focused on the discovery of fl-lactam antibiotics.* While