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Addition of Ester Enolates to N -Alkyl-2-fluoropyridinium Salts: Total Synthesis of (±)-20-Deoxycamptothecin and (+)-Camptothecin

✍ Scribed by Bennasar, M.-Lluïsa; Zulaica, Ester; Juan, Cecília; Alonso, Yolanda; Bosch, Joan


Book ID
119993184
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
214 KB
Volume
67
Category
Article
ISSN
0022-3263

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The addition reaction of samarium enolates and 2-haloenolates derived from esters and amides to imines takes place in an efficient manner. A novel protocol to perform the addition reaction of samarium enolates derived from esters or amides to chiral 2-aminoimines, with total stereoselectivity and wi