Addition of borane-protected secondary phosphines to imines. A route to protected mono-N-substituted-α-aminophosphines

✍ Scribed by Batia Ben-Aroya Bar-Nir; Moshe Portnoy

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 122 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00993-x

✦ Synopsis

Addition of a secondary phosphine±borane adduct to imines was examined in order to improve the synthesis of mono-N-substituted-a-aminophosphines. The reaction demonstrates, for the ®rst time, successful addition of a phosphine±borane to a multiple carbon±nitrogen bond. The process tolerates a range of substituents on the imine and results in an ecient formation of a borane-protected a-aminophosphine. Borane protects the aminophosphine and improves the reliability of the Mannich-like phosphine addition to imines.